Is there a link between COVID-19 and Creutzfeldt-Jakob Disease? a Case Report

Creutzfeldt-Jakob Disease (CJD) is a rare rapidly progressive neurodegenerative disease. The diagnosis of CJD based on magnetic resonance imaging (MRI) findings, electro-encephalography (EEG), or 14-3-3 protein detection. We report case previously-healthy 72 years old woman, with evidence coronavirus disease 2019 (COVID-19), who complained behavioral changes and dementia. While hospitalization, she didn't have orientation to time place repeated an irrelevant sentence in response questions. Also, anomia impaired comprehension was observed. Myoclonic jerks, abnormal signal intensity at bilateral parieto-occipital cortices MRI, periodic sharp wave complexes EEG, increased lactate dehydrogenase cerebrospinal fluid (CSF), highly recommended for her. This the second after COVID-19 during this pandemic, which can be alarm clinicians about silent impact central nervous system.